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Updated: Aug 23, 2025

Assessing Cardiac Reprogramming using High Content Imaging Analysis

Assessing Cardiac Reprogramming using High Content Imaging Analysis

Published on: October 26, 2020

Direct cardiac reprogramming: basics and future challenges.

Andrianto Andrianto¹, Eka Prasetya Budi Mulia², Kevin Luke³

¹Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Hospital, Mayjen Prof. Dr. Moestopo Street No.6-8, 60286, Surabaya, Indonesia. andrianto@fk.unair.ac.id.

Molecular Biology Reports

|October 29, 2022

Summary

This summary is machine-generated.

Direct cardiac reprogramming shows promise for heart failure by converting fibroblasts into cardiomyocytes. However, challenges in efficiency and safety must be addressed for clinical use.

Keywords:

Cardiomyocyte Direct reprogramming Fibroblast Pluripotent microRNA

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In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

In vitro Assessment of Cardiac Reprogramming by Measuring Cardiac Specific Calcium Flux with a GCaMP3 Reporter

Published on: February 22, 2022

Area of Science:

Regenerative Medicine
Cardiovascular Biology
Cellular Reprogramming

Background:

Heart failure is a major global health burden, leading to reduced cardiac function.
Current treatments like cardiac transplantation are limited by donor availability.
Novel regenerative strategies are crucial for treating end-stage heart failure.

Purpose of the Study:

To review the current status and challenges of direct cardiac reprogramming for clinical applications.
To explore strategies for converting cardiac fibroblasts into functional cardiomyocytes.
To identify key hurdles for the therapeutic use of cardiac reprogramming.

Main Methods:

A narrative review of existing literature on cardiac reprogramming.
Identification of key transcription factors for fibroblast-to-cardiomyocyte conversion.
Exploration of microRNA and small molecules to optimize reprogramming.

Main Results:

Direct reprogramming of cardiac fibroblasts into cardiomyocytes is a novel regenerative strategy.
Transcription factors, microRNA, and small molecules are key components of this process.
Challenges include conversion efficiency, viral methods, cell immaturity, reproducibility, and fibroblast depletion effects.

Conclusions:

Direct cardiac reprogramming strategies have demonstrated positive outcomes.
Significant improvements and challenges must be overcome for human therapeutic applications.
Further research is essential to advance cardiac reprogramming in regenerative therapy.