Precise oral delivery systems for probiotics: A review.

Area of Science:

• Microbiology
• Biotechnology
• Gastroenterology

Background:

• Probiotics offer health benefits but face survival challenges due to stomach acid, enzymes, and bile salts.
• Low viability and impaired function of probiotics necessitate protective delivery systems.
• Current delivery systems aim to enhance probiotic survival during gastric transit.

Purpose of the Study:

• To review probiotic delivery systems designed to overcome gastrointestinal challenges.
• To discuss the application of non-targeted and targeted delivery systems in various gut conditions.
• To explore the therapeutic potential of probiotic delivery systems as adjuvants in disease treatment.

Main Methods:

• Review of current literature on probiotic delivery systems.
• Analysis of trigger mechanisms for probiotic release in the intestine.
• Evaluation of non-targeted and targeted delivery strategies.

Main Results:

• Various probiotic delivery systems have been developed to ensure high viability in the intestine.
• Non-targeted delivery systems are prevalent, but face limitations in disease states.
• Targeted delivery systems show promise but require further development.

Conclusions:

• Probiotic delivery systems are essential for maintaining viability and function.
• Optimization of non-targeted systems and development of precisely targeted systems are needed.
• Further research into targeted probiotic delivery is crucial for managing gut diseases.