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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
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What We Have Learned from The Testosterone Trials.

Peter J Snyder1

  • 1Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

The Urologic Clinics of North America
|October 29, 2022
PubMed
Summary

Testosterone therapy in older men with low levels can improve sexual function, bone density, and mood slightly. However, effects on heart disease and prostate health require further investigation.

Keywords:
HemoglobinLate-onset hypogonadismSexual functionTestosteroneVolumetric bone mineral density

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Area of Science:

  • Endocrinology
  • Geriatrics
  • Men's Health

Background:

  • Serum total testosterone slightly declines with age.
  • Increased sex hormone-binding globulin lowers free testosterone in aging men.
  • Low testosterone levels in elderly men are a growing concern.

Purpose of the Study:

  • To evaluate the effects of testosterone treatment in elderly men with low testosterone.
  • To assess the impact on sexual function, physical performance, and mood.
  • To investigate changes in bone mineral density and cardiovascular markers.

Main Methods:

  • Analysis of data from testosterone trials involving elderly men.
  • Measurement of various health parameters before and after testosterone administration.
  • Assessment of changes in sexual function, hemoglobin, bone density, walking ability, vitality, and mood.

Main Results:

  • Testosterone therapy moderately improved sexual function, hemoglobin, and bone mineral density.
  • Slight improvements were observed in walking, vitality, and mood.
  • Testosterone treatment led to an increase in coronary artery noncalcified plaque volume.

Conclusions:

  • Testosterone treatment offers moderate benefits for specific health aspects in aging men with low levels.
  • The impact of testosterone therapy on long-term clinical heart disease and prostate disease remains unknown.
  • Further large-scale, long-term studies are needed to clarify risks and benefits.