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DNA methylation alternation in Stanford- A acute aortic dissection
Yufei Chen1, Xu Xu1, Zhaoran Chen1,2
1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
BMC Cardiovascular Disorders
|October 30, 2022
Summary
DNA methylation patterns are significantly altered in acute aortic dissection (AAD), impacting genes involved in cardiovascular disease progression. This study identifies key genes and pathways affected by these epigenetic changes.
Area of Science:
- Cardiovascular Biology
- Epigenetics
- Molecular Pathology
Background:
- Acute aortic dissection (AAD) is a critical cardiovascular condition.
- Emerging evidence suggests DNA methylation plays a role in AAD pathogenesis.
- A comprehensive understanding of DNA methylation in AAD is needed.
Purpose of the Study:
- To investigate the DNA methylation landscape in Stanford-A AAD.
- To identify specific genes and pathways epigenetically regulated in AAD.
- To validate the role of DNA methylation in AAD gene expression.
Main Methods:
- Screening of DNA methylation using the Infinium Human Methylation 450K BeadChip in aortic tissues.
- Gene enrichment analysis via KEGG pathways and Gene Ontology (GO).
- Validation of DNA methylation and protein expression in a replication cohort.
Main Results:
- Identified 589 differentially methylated positions in AAD aortic tissues.
- Associated genes were enriched in MAPK signaling, TNF signaling, and apoptosis pathways.
- Validated differential DNA methylation in key genes (Fas, ANGPT2, DUSP6, FARP1, CARD6) and increased Fas protein expression.
Conclusions:
- Significant alterations in DNA methylation occur in the aortic tissues of Stanford-A AAD patients.
- These epigenetic changes are linked to gene dysregulation implicated in AAD progression.
- DNA methylation may serve as a regulatory mechanism in the development of AAD.
