Related Experiment Video
Updated: Aug 23, 2025
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
517
Malignant solid tumor associated with hypereosinophilic syndrome
Livia Lontai1, Dorottya Angyal2, Anikó Folhoffer1
11 Semmelweis Egyetem, Általános Orvostudományi Kar, Belgyógyászati és Onkológiai Klinika Budapest, Korányi S. u. 2/a, 1083 Magyarország.
Orvosi Hetilap
|October 30, 2022
Summary
Hypereosinophilic syndrome, a condition of excess eosinophils, can mimic hematologic malignancy. This case highlights pancreatobiliary carcinoma presenting as hypereosinophilic syndrome, emphasizing early biopsy for diagnosis.
Area of Science:
- Hematology
- Oncology
- Gastroenterology
Background:
- Hypereosinophilic syndrome (HES) involves chronic eosinophil overproduction, leading to organ damage.
- Etiologies include myeloproliferative disorders, infections, tumors, lymphomas, and idiopathic causes.
Observation:
- A 49-year-old male presented with weight loss, edema, and tachycardia.
- Laboratory tests revealed elevated biliary parameters, extreme leukocytosis, and eosinophilia.
- Imaging showed hepatosplenomegaly, liver lesions, pancreatic cyst, lymphadenopathy, and pleural effusion.
Findings:
- Initial suspicion was hematologic malignancy (e.g., chronic myeloid leukemia), but diagnostic tests were inconclusive.
- Further investigation revealed liver metastases from a poorly differentiated epithelial tumor.
- Biopsy confirmed pancreatobiliary carcinoma as the cause of HES.
Implications:
- This case underscores the importance of considering gastrointestinal solid tumors in the differential diagnosis of HES.
- It highlights the diagnostic challenge posed by HES mimicking hematologic disorders.
- Early biopsy of solid lesions is crucial for accurate diagnosis and timely management of HES.
