Cortical gradient of a human functional similarity network captured by the geometry of cytoarchitectonic organization

Mapping the functional topology from a multifaceted perspective and relating it to underlying cross-scale structural principles is crucial for understanding the structural-functional relationships of the cerebral cortex. Previous works have described a sensory-association gradient axis in terms of coupling relationships between structure and function, but largely based on single specific feature, and the mesoscopic underpinnings are rarely determined. Here we show a gradient pattern encoded in a functional similarity network based on data from Human Connectome Project and further link it to cytoarchitectonic organizing principles. The spatial distribution of the primary gradient follows an inferior-anterior to superior-posterior axis. The primary gradient demonstrates converging relationships with layer-specific microscopic gene expression and mesoscopic cortical layer thickness, and is captured by the geometric representation of a myelo- and cyto-architecture based laminar differentiation theorem, involving a dual origin theory. Together, these findings provide a gradient, which describes the functional topology, and more importantly, linking the macroscale functional landscape with mesoscale laminar differentiation principles.