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Disease Progression of Hospitalized Elderly Patients with Omicron BA.2 Treated with Molnupiravir

Yayun Liu1, Lingling Ge1, Shiyong Fan2

  • 1Department of Infectious Diseases, First Hospital of Navy Military Medical University, 168 Changhai Road, Shanghai, 200433, China.

Infectious Diseases and Therapy
|October 31, 2022
PubMed
Abstract

Insights

Molnupiravir (MLN) effectively reduces viral load and hospital stay in elderly Omicron BA.2 patients. Early MLN treatment in older adults accelerates undetectable viral load and shortens hospitalization duration.

Area of Science:

  • Virology
  • Geriatric Medicine
  • Infectious Diseases

Background:

  • Molnupiravir (MLN) efficacy against Omicron sublineages is a growing concern.
  • Limited data exists on MLN effectiveness in elderly patients with Omicron BA.2 infections.

Purpose of the Study:

  • To evaluate the effectiveness of molnupiravir (MLN) in older adults diagnosed with Omicron BA.2.
  • To assess MLN's impact on viral load undetectability and disease progression in elderly COVID-19 patients.

Main Methods:

  • Retrospective review of elderly (over 60 years) COVID-19 patients diagnosed with Omicron BA.2.
  • Data collected from Chinghai Hospital, Shanghai, between March 26 and May 31, 2022.
  • Outcomes included undetectable viral load (VL) and disease progression (mortality, oxygen use, ICU admission).

Main Results:

  • Molnupiravir (MLN) use was associated with a rapid undetectable viral load (VL) at day 10.
  • Elderly patients receiving MLN were 7.584 times more likely to achieve undetectable VL.
  • MLN users experienced a 2.5-day reduction in median hospital stay compared to standard care.

Conclusions:

  • Early initiation of molnupiravir (MLN) in elderly COVID-19 patients accelerates viral load undetectability.
  • MLN treatment in older adults with Omicron BA.2 is linked to a shorter hospital stay.
Keywords:
AntimicrobialAntiviralCovid-19Elderly patientExacerbationMolnupiravirSARS-CoV-2

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