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Patient-specific risk factors contributing to blood culture contamination
Sidra Liaquat1, Lorena Baccaglini1, Gleb Haynatzki2
1Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska.
Objective:
Contaminated blood cultures result in extended hospital stays and unnecessary antibiotic therapy. Patient-specific factors associated with blood culture contamination remain largely unexplored. Identifying patients at higher risk of blood culture contamination could alert healthcare providers to take extra precautionary measures to limit contamination in these patients, and thereby prevent associated adverse outcomes. We sought to identify patient-related factors that contribute to blood culture contamination in hospitalized patients.
Design And Setting:
We conducted a secondary data analysis of a retrospective cohort study at an academic medical center.
Patients:
Study participants included 19,255 adult patients who had blood culture(s) performed during a hospital admission between June 2014 and December 2016.
Methods:
Data were analyzed to evaluate risk factors for blood culture contamination using logistic regression.
Results:
Among adult patients, we identified 464 contaminated episodes and 11,010 negative blood-culture episodes. Chronic obstructive pulmonary disease (adjusted odds ratio [AOR], 1.67; 95% confidence interval [CI], 1.20-2.34) and stay in an intensive care unit (ICU) during an admission (AOR, 1.41; 95% CI, 1.14-1.74) were associated with blood culture contamination. Other risk factors included race, body mass index, and admission from the emergency department. Subgroup analyses of patients admitted from the emergency department showed similar results.
Conclusions:
We identified patient-specific factors that increase the odds of false-positive blood cultures. By introducing mitigation strategies to limit contamination in patients with these risk factors, it may be possible to reduce the adverse clinical impact of blood culture contamination.
Insights
Identifying patients at higher risk for blood culture contamination is crucial. Chronic obstructive pulmonary disease and intensive care unit stays increase contamination odds, enabling targeted prevention strategies.
Area of Science:
- Clinical Microbiology
- Infectious Diseases
- Healthcare Epidemiology
Background:
- Blood culture contamination leads to prolonged hospital stays and unnecessary antibiotic use.
- Patient-specific risk factors for blood culture contamination are not well understood.
- Identifying at-risk patients can guide preventative measures to improve patient outcomes.
Purpose of the Study:
- To identify patient-related factors associated with blood culture contamination in hospitalized adults.
- To inform targeted interventions aimed at reducing false-positive blood culture results.
Main Methods:
- Retrospective cohort study involving secondary data analysis.
- Inclusion of 19,255 adult patients with blood cultures drawn between June 2014 and December 2016.
- Logistic regression analysis to determine risk factors for contamination.
Main Results:
- Chronic obstructive pulmonary disease (AOR 1.67) and intensive care unit (ICU) admission (AOR 1.41) were significantly associated with blood culture contamination.
- Additional risk factors identified include race, body mass index, and emergency department admission.
- Subgroup analysis confirmed similar risk factors for patients admitted from the emergency department.
Conclusions:
- Patient-specific factors, including chronic obstructive pulmonary disease and ICU stay, elevate the risk of blood culture contamination.
- Implementing targeted mitigation strategies for high-risk patients can reduce the clinical impact of false-positive blood cultures.
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