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Published on: February 12, 2017
Outcomes and Factors Associated with Completion of Radium-223 Therapy
Richard F Liu1, Lamin Juwara2, Cristiano Ferrario3
1Department of Nuclear Medicine, Jewish General Hospital, 3755 Chem. de la Côte-Sainte-Catherine, Montreal, QC H3T 1E2 Canada.
Radium-223 improves survival in prostate cancer patients. However, high baseline alkaline phosphatase (ALP) and prostate-specific antigen (PSA) predict lower completion rates in real-world use.
Area of Science:
- Oncology
- Radiopharmaceuticals
Background:
- Radium-223 is approved for castration-resistant prostate cancer (CRPC) with bone metastases.
- Its real-world effectiveness and factors influencing treatment completion require further characterization.
Purpose of the Study:
- To evaluate patient outcomes with radium-223 in a routine clinical setting.
- To identify factors associated with completing the 6-dose radium-223 regimen.
- To determine predictors of alkaline phosphatase (ALP) response.
Main Methods:
- Retrospective analysis of 36 patients treated with radium-223.
- Logistic regression used to identify factors for treatment completion and ALP response.
Main Results:
- 21/36 patients completed the 6-dose regimen.
- 15 patients achieved a 30% decrease in ALP.
- Elevated baseline ALP and PSA levels were associated with lower treatment completion rates.
- Prior chemotherapy for CRPC predicted a lower likelihood of ALP response.
Conclusions:
- Baseline ALP and PSA levels are associated with reduced radium-223 completion rates.
- Prior chemotherapy negatively impacts ALP response to radium-223.
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