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Detection of SARS-COV-2 by functionally imprinted micelles.

Lance R Hubbard¹, Caleb J Allen¹, Amy C Sims¹

¹Pacific Northwest National Laboratory, Richland, Washington, DC USA.

MRS Communications

|October 31, 2022

Summary

This study presents a novel micelle-based electrochemical cell for near real-time detection of airborne particles. The imprinted micelle technology demonstrates selective detection of analytes like SARS-COV-2, crucial for threat avoidance.

Keywords:

Bioelectronic COVID 19 Microscale Nanostructure Tunable

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Area of Science:

Nanotechnology
Analytical Chemistry
Biosensing

Background:

The need for rapid detection of airborne particles of interest is critical for addressing current and future threats.
Existing methods may lack the sensitivity or speed required for real-time monitoring.

Purpose of the Study:

To develop a micelle-based electrochemical cell for the near real-time detection of airborne particles.
To demonstrate the selectivity and sensitivity of imprinted micelle technology for specific analytes.

Main Methods:

Incorporation of imprinted particles into a micelle-based electrochemical cell.
Detection of analytes (e.g., SARS-COV-2) through specific imprinting and signal generation.
Testing selectivity against particles of similar size and morphology.
Compatibility assessment with airborne aerosol sampling techniques.

Main Results:

The developed system generated nanoamp-scale signals, potentially from individual virus-micelle interactions.
The technology exhibited selectivity when challenged with particles of comparable size and morphology.
The system proved compatible with airborne aerosol sampling methods.

Conclusions:

Imprinted micelle technology offers a promising approach for near real-time detection of airborne analytes.
This technology can be applied to a wide range of analytes of interest in various fields.
The system's sensitivity and selectivity are key advantages for threat detection and monitoring.