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Advances in pathogenesis and treatment of essential hypertension

Jun Ma1, Xiaoping Chen1

  • 1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Frontiers in Cardiovascular Medicine
|October 31, 2022
PubMed

Insights

Essential hypertension, a complex condition, has new research on its causes and treatments. This review highlights advances to improve prevention and management of high blood pressure.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Public Health

Background:

  • Hypertension is a major global health issue, causing cardiovascular and cerebrovascular diseases and premature death.
  • Essential hypertension, the most common form, has a complex and incompletely understood pathogenesis.
  • Current understanding presents a bottleneck in effectively preventing and treating this condition.

Purpose of the Study:

  • To review recent advances in understanding the pathogenesis of essential hypertension.
  • To highlight novel therapeutic strategies emerging from new etiological insights.
  • To provide updated knowledge for the prevention and treatment of essential hypertension.

Main Methods:

  • Comprehensive literature review of recent studies on essential hypertension.
  • Analysis of emerging findings in the pathogenesis of hypertension.
  • Synthesis of new treatment approaches linked to etiological discoveries.

Main Results:

  • Significant progress has been made in elucidating various aspects of essential hypertension pathogenesis.
  • New therapeutic targets and strategies have been identified based on these advances.
  • The review consolidates current knowledge, offering a foundation for future research and clinical practice.

Conclusions:

  • Recent research offers promising insights into the complex mechanisms of essential hypertension.
  • Novel therapeutic avenues are emerging, potentially improving patient outcomes.
  • This review provides a valuable resource for researchers and clinicians focused on hypertension management.

Keywords:
arterial stiffnessessential hypertensiongenetics - clinicalsalt-sensitivesympathetic dysregulation

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