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Solid-Liquid Equilibrium Behavior and Solvent Effect of Gliclazide in Mono- and Binary Solvents
Zihao Wang1,2, Shuai Yu1,3,4, Hongcheng Li4
1School of Pharmaceutical Sciences, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), 19 Keyuan Road, Lixia District, Jinan250014, Shandong, P. R. China.
ACS Omega
|October 31, 2022
Summary
This study measured gliclazide solubility in various solvents and correlated the data using thermodynamic models. The Apelblat model demonstrated the best fit for both single and mixed solvent systems.
Area of Science:
- Physical Chemistry
- Pharmaceutical Science
Background:
- Gliclazide is an important antidiabetic drug.
- Understanding its solubility is crucial for formulation development.
Purpose of the Study:
- To determine gliclazide solubility in various organic solvents and a binary solvent mixture.
- To evaluate solvent effects on gliclazide solubility using Hansen solubility parameters and KAT-LSER.
- To correlate experimental solubility data using six thermodynamic models.
Main Methods:
- Gravimetric method for solubility determination.
- Hansen solubility parameters and KAT-LSER for solvent effect analysis.
- Correlation using λh, Yaws, Apelblat, Jouyban, modified Jouyban-Acree, and Sun models.
Main Results:
- Solubility data of gliclazide were obtained in 10 mono-solvents and one binary solvent (DMA + water) from 278.15 to 323.15 K.
- Hansen solubility parameters and KAT-LSER provided insights into solubility trends and solvent influences.
- All six thermodynamic models showed good correlation with the experimental data.
Conclusions:
- The Apelblat model was identified as the most suitable for correlating gliclazide solubility data in both mono- and binary solvent systems.
- This research provides valuable data for optimizing gliclazide formulations.
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