Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cerebellar gray matter volume alterations and metabolic associations stratified by disease duration in patients with type 2 diabetes.

Brain research bulletin·2026
Same author

Coal Dust-Mimetic Carbon Nanoparticles Induce Colonic Epithelial Cell Senescence via p16/p21 Dual Pathways and Promote Colonic Inflammatory Response.

Journal of gastroenterology and hepatology·2026
Same author

Socioeconomic inequalities in online fresh food delivery use and associations with the neighborhood food environment.

BMC public health·2026
Same author

Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention.

BMC medicine·2026
Same author

Hypervirulent <i>Klebsiella pneumoniae</i> induces liver abscess by promoting neutrophil extracellular trap formation through NLRP3 inflammasome activation.

Microbiology spectrum·2026
Same author

Perioperative oxygen therapy, oxidative stress, and cardiac outcomes.

Minerva anestesiologica·2026

Related Experiment Video

Updated: Aug 23, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.7K

Estrogen Sulfotransferase Induction Inhibits Breast Cancer Cell Line MCF-7 Proliferation.

Weiyu Jiang1, Zhao Dai1,2, Guangping Chen1

  • 1Department of Physiological Sciences, Center for Veterinary Health Sciences, USA.

Biomedical Journal of Scientific & Technical Research
|October 31, 2022
PubMed
Summary
This summary is machine-generated.

Nutritional flavonoids can up-regulate estrogen sulfotransferase (SULT1E1), inhibiting estrogen-dependent breast cancer cell proliferation. This suggests flavonoids may offer new strategies for cancer prevention and treatment, potentially as co-drugs with existing therapies.

Keywords:
Breast Cancer TreatmentEstrogen SulfotransferaseEstrogen-Dependent Breast CancerFlavonoidGene RegulationPreventionQuercetin

More Related Videos

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.3K
Mammary Epithelial and Endothelial Cell Spheroids as a Potential Functional In vitro Model for Breast Cancer Research
08:30

Mammary Epithelial and Endothelial Cell Spheroids as a Potential Functional In vitro Model for Breast Cancer Research

Published on: July 12, 2021

4.7K

Related Experiment Videos

Last Updated: Aug 23, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.7K
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

20.3K
Mammary Epithelial and Endothelial Cell Spheroids as a Potential Functional In vitro Model for Breast Cancer Research
08:30

Mammary Epithelial and Endothelial Cell Spheroids as a Potential Functional In vitro Model for Breast Cancer Research

Published on: July 12, 2021

4.7K

Area of Science:

  • Endocrinology
  • Oncology
  • Nutritional Biochemistry

Background:

  • Estrogen-dependent cancers, particularly breast cancer, are a major health concern.
  • Current treatments target estrogen receptors (ERs) or estrogen synthesis (aromatase, steroid sulfatase).
  • Estrogen inactivation via estrogen sulfotransferase (SULT1E1) is an underexplored therapeutic target.

Purpose of the Study:

  • To investigate the potential of up-regulating SULT1E1 for treating estrogen-dependent cancers.
  • To explore the effect of nutritional flavonoids on SULT1E1 activity and cancer cell proliferation.
  • To evaluate flavonoids as potential preventative agents or co-drugs in cancer therapy.

Main Methods:

  • Utilized estrogen-dependent breast cancer MCF-7 cells.
  • Assessed the impact of nutritional flavonoids on SULT1E1 expression and activity.
  • Measured the effect of flavonoids on cancer cell proliferation, both alone and in combination with other drugs.

Main Results:

  • Certain nutritional flavonoids were found to induce SULT1E1 expression and activity.
  • Flavonoids significantly inhibited proliferation in MCF-7 breast cancer cells.
  • SULT1E1 inducers showed additive or synergistic effects when combined with established breast cancer drugs.

Conclusions:

  • Up-regulating SULT1E1 through nutritional flavonoids presents a novel therapeutic strategy for estrogen-dependent cancers.
  • Flavonoids are safe, inexpensive, and could be used for cancer prevention or as co-drugs.
  • This research opens avenues for developing innovative treatments and drugs for breast and endometrial cancers.