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Updated: Aug 23, 2025

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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Aptamer-based applications for cardiovascular disease.

Xinyuan Chen1, Yue Ma1, Yuquan Xie1

  • 1Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Frontiers in Bioengineering and Biotechnology
|October 31, 2022
PubMed
Summary
This summary is machine-generated.

Aptamers, novel oligonucleotide tools, show promise in diagnosing and treating cardiovascular diseases like atherosclerosis. Targeting molecules such as von Willebrand Factor, aptamers offer integrated diagnostic and therapeutic strategies for cardiac conditions.

Keywords:
antithrombotic therapyaptameratherosclerosiscardiovascular diseaseprecision medicinevon Willebrand factor

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Area of Science:

  • Biotechnology and Biomedical Engineering
  • Cardiovascular Medicine
  • Oligonucleotide Therapeutics

Background:

  • Cardiovascular diseases, particularly atherosclerosis, represent a leading global cause of mortality, necessitating innovative diagnostic and therapeutic solutions.
  • Aptamers, single-stranded oligonucleotides with high specificity and affinity, are emerging as powerful alternatives to antibodies in cardiac applications due to their unique structural properties and ease of chemical synthesis and modification.
  • Von Willebrand Factor (vWF) is a critical mediator in thrombus formation, making it a key target for antithrombotic strategies.

Purpose of the Study:

  • To review and summarize the current applications of aptamers in the diagnosis and treatment of cardiovascular diseases.
  • To explore the potential of aptamer-based strategies for biomarker discovery and future management of cardiac conditions.
  • To highlight the role of aptamers in integrating diagnostic and therapeutic functions for improved cardiovascular care.

Main Methods:

  • Literature review of aptamer-based applications in cardiovascular disease research.
  • Analysis of aptamer engineering for site-specific modifications and therapeutic development.
  • Evaluation of aptamer targeting of molecules like von Willebrand Factor for antithrombotic effects.

Main Results:

  • Aptamers demonstrate significant potential in diagnosing cardiac diseases and developing anti-thrombosis therapeutics.
  • Targeting von Willebrand Factor with aptamers has shown initial success in inhibiting blood clot progression, offering diagnostic and therapeutic benefits.
  • Aptamer-vWF combinations present a novel strategy for improving the biocompatibility of medical devices like drug-eluting balloons and stents.

Conclusions:

  • Aptamers are promising agents for the integrated diagnosis and therapy of cardiovascular diseases.
  • The development of aptamer-based tools offers novel strategies for biomarker discovery and enhanced management of cardiac conditions.
  • Further research into aptamer applications holds the potential to significantly advance cardiovascular medicine.