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The Correlation between the Triglyceride-Glucose Index and Coagulation Markers in Patients with Recent Acute
Daniel Košuta1,2, Marko Novaković1,2, Mojca Božič Mijovski2,3
1Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Insights
The triglyceride-glucose (TyG) index, a marker for metabolic syndrome, correlates with hypercoagulability in coronary artery disease (CAD) patients. This suggests metabolic syndrome may drive atherothrombotic risk in CAD.
Area of Science:
- Cardiology
- Metabolic Syndrome Research
- Hemostasis and Thrombosis
Background:
- Metabolic abnormalities and hypercoagulability are significant predictors in coronary artery disease (CAD).
- The triglyceride-glucose (TyG) index is a recognized marker for metabolic syndrome with predictive value for cardiovascular events.
- Overall hemostatic potential (OHP) is a reliable measure for identifying hypercoagulability in CAD patients.
Purpose of the Study:
- To investigate the correlation between the triglyceride-glucose (TyG) index and hemostatic derangements in patients with coronary artery disease (CAD).
Main Methods:
- The study included 117 patients post-acute myocardial infarction.
- Measurements included overall hemostatic potential (OHP), overall coagulation potential (OCP), overall fibrinolytic potential (OFP), fibrinogen, D-dimer, and von Willebrand factor.
- The triglyceride-glucose (TyG) index was calculated, and linear regression models were used for multivariate analysis.
Main Results:
- A significant correlation was observed between the TyG index and overall coagulation potential (OCP) (r=0.229, p=0.026).
- The TyG index also correlated with OHP (r=0.202, p=0.050) and fibrinogen levels (r=0.271, p=0.005).
- In multivariate analysis, the TyG index remained significantly correlated with OCP (beta=2.08, p=0.042) and fibrinogen (beta=0.35, p=0.012).
Conclusions:
- The triglyceride-glucose (TyG) index shows a strong correlation with a hypercoagulable state in CAD patients, indicated by OCP and elevated fibrinogen.
- These findings suggest that metabolic syndrome, as indicated by the TyG index, may be a key factor contributing to atherothrombotic risk in CAD.
Background:
Metabolic abnormalities and hypercoagulability seem to have an important predictive role in patients with coronary artery disease (CAD). The triglyceride-glucose (TyG) index has emerged as a good marker for metabolic syndrome with predictive value for cardiovascular events. Overall haemostatic potential (OHP) is a reliable global haemostatic essay to identify hypercoagulability in CAD patients. The aim of our study was therefore to evaluate a possible correlation between the TyG index and haemostatic derangements in patients with CAD.
Methods:
Consecutive patients referred for the first follow-up visit after acute myocardial infarction between December 1, 2018, and March 31, 2020, and did not meet exclusion criteria were included. We determined OHP, overall coagulation potential (OCP), overall fibrinolytic potential (OFP), fibrinogen, D-dimer, and von Willebrand factor from peripheral blood samples. The TyG index was calculated with the previously described and validated formula. Linear regression models were constructed for the multivariate analysis.
Results:
A total of 117 patients (mean age 56 ± 10 years, 20% women) were included. A correlation was found between TyG index and OCP (r = 0.229, p = 0.026), TyG index and OHP (r = 0.202, p = 0.050), and TyG index and fibrinogen (r = 0.271, p = 0.005). In the multivariate model which accounted for sex, age, and BMI, the correlation between TyG index and OCP (R 2 0.108; ANOVA for regression p = 0.035; beta 2.08 [0.79-4.01], p = 0.042) and between TyG index and fibrinogen (R 2 0.11; ANOVA for regression p = 0.015; beta 0.35 [0.08-0.62], p = 0.012) emerged as statistically significant.
Conclusion:
The TyG index, a marker of metabolic syndrome, has a strong correlation with a hypercoagulability state in CAD, as determined by the OCP and higher fibrinogen levels. Our findings suggest that metabolic syndrome may be an important driver of atherothrombotic risk in patients with CAD.
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