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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
282

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Functional brain changes using electroencephalography after a 24-week multidomain intervention program to prevent

Hee Kyung Park1,2, Seong Hye Choi3, SeonMyeong Kim4

  • 1Department of Neurology, Ewha Womans University School of Medicine, Seoul, South Korea.

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|October 31, 2022
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Summary

A 24-week lifestyle intervention improved brain function in at-risk elderly individuals. Quantitative electroencephalography (QEEG) showed increased functional connectivity and global efficiency, indicating positive neurophysiological changes.

Keywords:
biomarkerscognitive impairmentdementiamultidomain interventionquantitative electroencephalography

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Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Quantitative electroencephalography (QEEG) is valuable for predicting treatment responses.
  • No prior studies have examined QEEG-derived functional connectivity changes after lifestyle interventions.
  • The SUPERBRAIN study investigated a multidomain lifestyle intervention for at-risk elderly individuals.

Purpose of the Study:

  • To assess neurophysiological changes, specifically in QEEG-based functional connectivity, following a 24-week multidomain lifestyle intervention.
  • To compare changes between facility-based (FMI), home-based (HMI), and control groups.

Main Methods:

  • Participants (60-79 years) without dementia but with at least one modifiable risk factor were randomized.
  • EEG data were collected at baseline and study end for FMI (n=44), HMI (n=49), and control (n=34) groups.
  • Spectrum power, power ratio, source cortical current density, and functional connectivity (imaginary coherence, characteristic path length) were analyzed.

Main Results:

  • Intervention groups showed increased beta1 and beta3 band power and alpha1 band imaginary coherence compared to controls.
  • Participants receiving the intervention exhibited decreased alpha1 band characteristic path lengths in specific brain regions.
  • Positive neurophysiological changes, including enhanced functional connectivity and global efficiency, were observed post-intervention.

Conclusions:

  • A 24-week multidomain lifestyle intervention positively impacts neurophysiology in at-risk elderly individuals.
  • QEEG can detect biological changes associated with lifestyle interventions, suggesting potential for cognitive health.
  • Findings support the use of lifestyle interventions to promote brain health and potentially mitigate cognitive decline in aging populations.