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Updated: Aug 23, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Gut microbiota and obesity: New insights
Yoredy Sarmiento-Andrade1, Rosario Suárez1, Beatriz Quintero1
1School of Medicine, Universidad Técnica Particular de Loja, Loja, Ecuador.
Frontiers in Nutrition
|October 31, 2022
Summary
Obesity is a growing global health issue linked to the gut microbiome. This review explores the microbiome
Area of Science:
- Microbiome research
- Obesity and metabolic disorders
- Gut health
Background:
- Rising global obesity rates highlight the need to understand associated pathologies.
- The gut microbiome's influence on health and disease is increasingly recognized.
- Specific microbiome alterations are linked to obesity and related conditions.
Purpose of the Study:
- To review the biology and physiology of the gut microbiota in obese patients.
- To elucidate the role of the microbiome in obesity-associated disorders.
- To discuss emerging therapeutic strategies involving the microbiome.
Main Methods:
- Literature review of studies on obesity and the gut microbiome.
- Analysis of physiological and pathological roles of microbial communities.
- Examination of therapeutic interventions like prebiotics, probiotics, and FMT.
Main Results:
- Significant changes in gut microbiota composition are observed in obese individuals.
- Microbiota dysbiosis contributes to the pathophysiology of obesity-related diseases.
- Therapeutic modulation of the microbiome shows promise for obesity management.
Conclusions:
- The gut microbiota plays a critical role in obesity and its complications.
- Targeting the microbiome offers novel therapeutic avenues for obesity treatment.
- Further research into prebiotics, probiotics, and fecal microbiota transplantation is warranted.
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