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MicroRNA-383: A tumor suppressor miRNA in human cancer

Abdollah Jafarzadeh1,2, Majid Noori3, Shaghayegh Sarrafzadeh4

  • 1Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Frontiers in Cell and Developmental Biology
|October 31, 2022
PubMed

Insights

MicroRNA-383 (miR-383) acts as a tumor suppressor by inhibiting cancer cell growth and promoting apoptosis. Restoring miR-383 expression shows potential as a novel cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Downregulated expression of miR-383 is observed in numerous human cancers.
  • miR-383 functions as a tumor suppressor miRNA, inhibiting key oncogenic pathways.

Purpose of the Study:

  • To review the anti-tumor effects of miR-383 across various human cancers.
  • To highlight miR-383's downstream target genes and potential therapeutic applications.

Main Methods:

  • Literature review of studies investigating miR-383 in cancer.
  • Analysis of miR-383's targeting mechanisms and functional roles.

Main Results:

  • miR-383 inhibits cancer cell proliferation, invasion, migration, angiogenesis, and chemoresistance.
  • It also suppresses epithelial-mesenchymal transition, glycolysis, and cancer stem cell development, while promoting apoptosis.
  • miR-383 exhibits tumor-inhibitory roles in breast, lung, colorectal, and many other cancers, with exceptions in ovarian and cholangiocarcinoma.

Conclusions:

  • miR-383 is a potent tumor suppressor with broad anti-cancer activity.
  • Restoration of miR-383 expression represents a promising therapeutic strategy for various malignancies.
Keywords:
cancermiR-383miR-383-3pmir-383-5ptarget genes

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