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Related Experiment Video

Updated: Aug 23, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction.

Yu-Shen Yang1, Shi-Ling He1, Wei-Can Chen1

  • 1Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Frontiers in Cellular Neuroscience
|October 31, 2022
PubMed
Summary

Non-coding RNAs (ncRNAs) are implicated in postoperative cognitive dysfunction (POCD), a condition affecting elderly patients after surgery. Understanding ncRNA roles offers new diagnostic and therapeutic strategies for POCD.

Keywords:
circular RNA (circRNA)long non-coding RNA (lncRNA)microRNAnon-coding RNA (ncRNA)postoperative cognitive dysfunction (POCD)

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Postoperative cognitive dysfunction (POCD) is a significant complication, particularly in elderly patients, manifesting as cognitive and sensory impairments after surgery.
  • Current understanding of POCD pathogenesis involves neuroinflammation, apoptosis, oxidative stress, and protein aggregation (Aβ, tau), yet precise mechanisms remain elusive.

Purpose of the Study:

  • To review the role of non-coding RNAs (ncRNAs) in the pathogenesis and diagnosis of POCD.
  • To explore ncRNA-mediated mechanisms underlying POCD.
  • To identify ncRNAs as potential biomarkers for POCD diagnosis, treatment, and prognosis.

Main Methods:

  • Literature review focusing on ncRNAs (microRNA, long ncRNA, circular RNA) and their association with POCD.
  • Systematic discussion of ncRNA involvement in POCD pathogenesis.
  • Exploration of ncRNA-associated molecular mechanisms in POCD.

Main Results:

  • ncRNAs, including microRNAs, long ncRNAs, and circular RNAs, are suggested to play a crucial role in regulating POCD-related processes.
  • Evidence indicates ncRNAs are involved in key pathological pathways of POCD.
  • ncRNAs show potential as diagnostic biomarkers and therapeutic targets for POCD.

Conclusions:

  • ncRNAs are significantly implicated in the pathogenesis of POCD.
  • ncRNAs represent promising biomarkers for POCD diagnosis and prognosis.
  • Targeting ncRNAs may offer novel therapeutic avenues for managing POCD.