Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrative Transcriptomic Analysis Reveals Distinct and Shared Host Responses in Dengue and Chikungunya Infections.

International journal of molecular sciences·2026
Same author

Understanding and Exploiting Biological Mechanisms of Radiosensitization Using High Atomic Mass Nanomaterials.

Nanomaterials (Basel, Switzerland)·2026
Same author

A human airway-on-a-chip microphysiological system for modeling chlorine gas toxicity.

Toxicological sciences : an official journal of the Society of Toxicology·2025
Same author

Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model.

Journal of applied toxicology : JAT·2025
Same author

Farnesol emulsion for elimination of <i>Pseudomonas aeruginosa</i> biofilm in a 3D airway model of cystic fibrosis.

Biofilm·2025
Same author

Silica-Based Fiber Universal Combat Matrix Reduces Inflammation, Supporting Cellular Migration and Extracellular Matrix Remodeling in Porcine Full-Thickness Burns.

Military medicine·2025

Related Experiment Video

Updated: Aug 23, 2025

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
07:59

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions

Published on: September 10, 2021

3.2K

Organoid Technologies for SARS-CoV-2 Research.

Khiry Sutton1, Timothy Leach1, Vikram Surendran1

  • 1Wake Forest Institute for Regenerative Medicine, 391 Technology Way NE, Winston-Salem, NC 27101 USA.

Current Stem Cell Reports
|October 31, 2022
PubMed
Summary

Organoids offer a superior in vitro model for studying viral infections like SARS-CoV-2, enabling accurate disease modeling and drug screening. These 3D models provide better insights into tissue responses and potential treatments compared to traditional methods.

Keywords:
3D culturesDrug screeningIn vitro modelsOrganoidsSARS-CoV-2TreatmentViral models

More Related Videos

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
10:12

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

8.5K
Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
09:26

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

585

Related Experiment Videos

Last Updated: Aug 23, 2025

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
07:59

Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions

Published on: September 10, 2021

3.2K
Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids
10:12

Establishing Human Lung Organoids and Proximal Differentiation to Generate Mature Airway Organoids

Published on: March 23, 2022

8.5K
Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
09:26

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

585

Area of Science:

  • Biomedical research
  • Infectious disease modeling
  • 3D cell culture technology

Background:

  • Organoids are advanced 3D in vitro models that mimic human organ and tissue systems.
  • Traditional 2D cell cultures and animal models can yield inaccurate disease modeling outcomes.
  • Organoids provide physiologically relevant platforms for studying tissue function and disease responses.

Purpose of the Study:

  • To review organoid technologies for modeling SARS-CoV-2 infection.
  • To highlight the utility of organoids in understanding viral effects on different organs.
  • To evaluate the efficacy of potential anti-viral treatments using organoid models.

Main Methods:

  • Utilizing established lung, cardiac, kidney, and small intestine organoid models.
  • Investigating SARS-CoV-2 infection dynamics within these organoids.
  • Assessing the effectiveness of various anti-viral drugs and therapeutic strategies.

Main Results:

  • Lung organoids reveal SARS-CoV-2 preferentially infects club cells and are useful for rapid anti-viral drug screening.
  • Kidney organoids suggest soluble ACE2 as a potential early-stage infection preventative.
  • Small intestine organoids aid in evaluating fecal-to-oral transmission routes, while cardiac organoids identify potential treatments like BET inhibitors.

Conclusions:

  • Organoids are effective tools for studying viral infections and evaluating drug efficacy.
  • They enable more accurate disease modeling and a better understanding of infection's physiological effects.
  • Organoid technology facilitates the identification of novel treatments and preventive strategies for viral diseases.