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Association between single nucleotide polymorphism SLCO1B1 gene and simvastatin pleiotropic effects measured through

Andrianto1, Mia Puspitasari2, Meity Ardiana2

  • 1Department of Cardiology and Vascular Medicine, Faculty of Medicine, Airlangga University - Dr. Soetomo General Hospital, Jl. Mayjen Prof. Dr. Moestopo No. 6-8, Surabaya 60286, Indonesia.

Therapeutic Advances in Cardiovascular Disease
|October 31, 2022
PubMed

Insights

This study found no link between the c.521T>C single nucleotide polymorphism (SNP) and simvastatin's effect on endothelial function, measured by flow-mediated dilation (FMD). However, simvastatin treatment duration was associated with FMD and blood pressure changes.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacogenomics
  • Molecular Biology

Background:

  • Atherosclerosis involves arterial inflammation and endothelial dysfunction.
  • Simvastatin, a cholesterol drug, has beneficial endothelial effects.
  • Genetic variations may influence simvastatin response, affecting its pleiotropic actions.

Purpose of the Study:

  • To investigate the association between the single nucleotide polymorphism (SNP) c.521T>C and simvastatin's pleiotropic effects.
  • To evaluate the impact of SNP c.521T>C on endothelial function, assessed by flow-mediated dilation (FMD).

Main Methods:

  • A multicentre cross-sectional study included 71 hypercholesterolemia patients on simvastatin for at least 3 months.
  • SNP c.521T>C was identified using real-time polymerase chain reaction.
  • Flow-mediated dilation (FMD) was measured via brachial artery ultrasonography.

Main Results:

  • The c.521T>C SNP (TC genotype) was present in 9.9% of patients and showed no significant association with FMD (p=0.973).
  • Logistic regression revealed that longer simvastatin treatment duration correlated with increased FMD (Adj. OR=2.424, p=0.025).
  • Simvastatin treatment duration was also linked to reduced systolic blood pressure (Adj. OR=0.92, p=0.001).

Conclusions:

  • No association was found between the c.521T>C SNP and flow-mediated dilation (FMD).
  • The duration of simvastatin therapy demonstrated a significant association with endothelial function (FMD).
  • Systolic blood pressure was also found to be associated with the duration of simvastatin treatment.
Abstract

Keywords:
SLCO1B1 geneflow-mediated dilationsimvastatinsingle nucleotide polymorphism

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