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Alpha 2-Heremans-Schmid glycoprotein gene polymorphism (rs4918) is associated with coronary artery calcification in

Shuqi Dai1, Yun Chen1, Da Shang1

  • 1Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.

Nephrology (Carlton, Vic.)
|October 31, 2022
PubMed

Insights

The AHSG gene polymorphism rs4918 is linked to coronary artery calcification (CAC) progression in peritoneal dialysis (PD) patients. This genetic variant influences serum fetuin-A levels, a key calcification inhibitor.

Area of Science:

  • Nephrology
  • Genetics
  • Cardiovascular Disease

Background:

  • Coronary artery calcification (CAC) is a severe complication in peritoneal dialysis (PD) patients.
  • Fetuin-A, a serum calcification inhibitor, is encoded by the alpha 2-Heremans-Schmid glycoprotein (AHSG) gene.

Purpose of the Study:

  • To investigate the association between AHSG gene polymorphism rs4918 and CAC in PD patients.
  • To examine the role of rs4918 in the progression of CAC among PD patients.

Main Methods:

  • Prospective study of 202 incident PD patients followed for 2 years.
  • CAC measurements at baseline and 2-year follow-up.
  • Analysis of AHSG gene polymorphism rs4918, serum fetuin-A, and clinical data using binary logistic regression.

Main Results:

  • Genotype GG of AHSG rs4918 was an independent risk factor for CAC (OR=2.153) and CAC progression (OR=2.482).
  • Serum fetuin-A levels showed a dose-dependent effect influenced by the number of G alleles in rs4918.

Conclusions:

  • AHSG gene polymorphism rs4918 impacts serum fetuin-A levels.
  • rs4918 is significantly associated with the presence and progression of CAC in PD patients.
Abstract

Keywords:
coronary artery calcificationfetuin-Agenotypeperitoneal dialysispolymorphism

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