Solitary labial papular acantholytic dyskeratoma in an immunocompromised host

A 42-year-old white man presented with a solitary labial papule 4 years after cardiopulmonary transplantation. Pathological examination of the excised papule revealed a tumor with prominent acantholytic dyskeratosis. Risk factors for skin tumors in this patient included habitual tobacco chewing, chronic unprotected solar exposure, and an immunosuppressive regimen comprising prednisone and cyclosporin-A. This is the first report of an acantholytic dyskeratoma in association with these predisposing conditions.