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Enhanced Inactivation of Pseudoparticles Containing SARS-CoV-2 S Protein Using Magnetic Nanoparticles and an
Pranto Paul1, Kearstin L Edmonds2, Kevin C Baldridge1
1Department of Chemical & Materials Engineering, University of Kentucky, Lexington, Kentucky40506-0046, United States.
ACS Applied Bio Materials
|October 31, 2022
Summary
Magnetic nanoparticles (MNPs) combined with alternating magnetic fields (AMF) show promise for inactivating SARS-CoV-2. This novel virus inactivation technology offers a potential strategy against current and future pandemics.
Area of Science:
- Biophysics
- Nanotechnology
- Virology
Background:
- The rapid spread of SARS-CoV-2 highlights the urgent need for effective virus inactivation technologies.
- SARS-CoV-2 infection relies on the spike glycoprotein's interaction with the ACE2 receptor, a target for inhibition.
Purpose of the Study:
- To investigate the efficacy of magnetic nanoparticles (MNPs) with alternating magnetic fields (AMF) for inactivating SARS-CoV-2.
- To compare AMF-based inactivation with conventional water bath (WB) heating methods.
Main Methods:
- Vesicular stomatitis virus pseudoparticles displaying the SARS-CoV-2 spike protein were exposed to AMF or WB.
- Exposures were conducted at target temperatures of 45, 50, and 55 °C for 5, 15, and 30 minutes.
Main Results:
- AMF exposures demonstrated significantly greater virus inactivation compared to WB at identical temperatures in several instances.
- Localized heating and MNP rotation induced by AMF are likely responsible for the enhanced inactivation.
Conclusions:
- The study presents a potential strategy for virus inactivation using magnetically mediated energy delivery (MagMED).
- This MNP-AMF approach offers a promising avenue for combating SARS-CoV-2 and future viral threats.
