Reduced circulating interleukin 35 is associated with enhanced peripheral T cell function in primary biliary
Siqi Liu1, Qian Zhang1, Mengyao Zhang1
1Digestive Disease Center, Department of Hepatopancreatobiliary Medicine, The Second Hospital, Jilin University, Changchun, Jilin Province, China.
Biomolecules & Biomedicine
|October 31, 2022
Summary
Reduced Interleukin 35 (IL-35) in primary biliary cholangitis (PBC) patients may impair T cell function, contributing to immune dysregulation. Lower IL-35 levels correlate with disease activity, suggesting a role in PBC pathogenesis.
Area of Science:
- Immunology
- Hepatology
- Autoimmune Diseases
Background:
- Interleukin 35 (IL-35) is known to suppress T cell activity in autoimmune conditions.
- The precise role of T cells and IL-35 in primary biliary cholangitis (PBC) pathogenesis remains unclear.
Purpose of the Study:
- To investigate the impact of IL-35 on T cell function in patients with primary biliary cholangitis.
- To explore the relationship between IL-35 levels and disease markers in PBC.
Main Methods:
- Quantified plasma IL-35 levels in 51 PBC patients and 28 controls.
- Stimulated CD4+ and CD8+ T cells with IL-35 in vitro to assess functional phenotypes.
- Co-cultured IL-35-treated CD8+ T cells with biliary epithelial cells to evaluate cytotoxicity.
Main Results:
- PBC patients exhibited lower plasma IL-35 concentrations, negatively correlating with alkaline phosphatase.
- In vitro IL-35 suppressed IL-17 and IL-22 production by CD4+ T cells and reduced CD8+ T cell cytotoxicity.
- IL-35 treatment increased immune checkpoint receptor expression on CD8+ T cells from PBC patients.
Conclusions:
- Reduced circulating IL-35 in PBC may lead to insufficient T cell suppression and subsequent immune dysregulation.
- These findings highlight a potential role for IL-35 in the immunopathogenesis of primary biliary cholangitis.
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