[Midazolam and pethidine/promethazine for intramuscular premedication]

Area of Science:

• Anesthesiology
• Pharmacology

Background:

• Premedication aims to reduce preoperative stress.
• Benzodiazepines are proven effective, yet opioid/neuroleptic combinations are often used.
• Investigating midazolam versus meperidine/promethazine for intramuscular premedication.

Purpose of the Study:

• To compare the efficacy and safety of midazolam and meperidine/promethazine for intramuscular premedication.
• To assess anxiolytic, antidepressive, and asthenia effects.
• To evaluate physiological stress, acceptance, and side effects.

Main Methods:

• Double-blind study involving 60 patients undergoing minor gynecological surgery.
• Random assignment to receive midazolam or meperidine/promethazine intramuscularly.
• Assessment of anxiety, depression, asthenia, sedation, vital signs, acceptance, and side effects.

Main Results:

• Midazolam demonstrated significantly superior anxiolytic and antidepressive effects.
• No significant differences were observed in other parameters besides adverse effects.
• Meperidine/promethazine group experienced significantly more side effects than the midazolam group.

Conclusions:

• Midazolam offers superior anxiolytic and antidepressive benefits with fewer side effects for premedication.
• Despite comparable patient acceptance post-surgery, midazolam is recommended over meperidine/promethazine.
• Anesthesiologists should consider midazolam for improved patient outcomes in intramuscular premedication.