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[OCULAR MANIFESTATIONS IN BEHÇET DISEASE]
Shaul Sar1, Oren Tomkins-Netzer1,2
1Department of Ophthalmology, Lady Davis Carmel Medical Center, Haifa, Israel.
Harefuah
|October 31, 2022
Summary
Ocular Behçet disease, a form of uveitis, affects most patients and can cause vision loss. Early diagnosis and treatment with immunosuppressants are crucial for preserving long-term vision.
Area of Science:
- Ophthalmology
- Rheumatology
- Immunology
Context:
- Behçet disease frequently involves the eyes, often presenting as panuveitis with retinal vasculitis.
- Recurrent ocular inflammation can lead to severe complications like macular edema and neovascularization, potentially causing vision loss.
- Ocular manifestations are a significant concern, impacting a substantial portion of patients.
Purpose:
- To highlight the importance of early diagnosis and treatment of ocular involvement in Behçet disease.
- To outline current diagnostic methods, including clinical findings and advanced imaging techniques.
- To review established and emerging therapeutic strategies for managing ocular Behçet disease.
Summary:
- Ocular involvement in Behçet disease is characterized by panuveitis and retinal vasculitis, frequently leading to vision-threatening complications.
- Diagnosis relies on clinical assessment and multimodal imaging, including fluorescein angiography and OCT.
- Treatment involves systemic corticosteroids and immunosuppressive agents, with anti-TNFα therapies being key second-line options.
Impact:
- Early intervention and comprehensive management can prevent irreversible vision loss.
- Effective treatment strategies aim to control inflammation, prevent relapses, and preserve long-term visual acuity.
- Understanding ocular Behçet disease is critical for improving patient outcomes and quality of life.
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