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Updated: Aug 23, 2025
05:52
Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
Published on: May 12, 2023
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Neutrophils in aging and aging-related pathologies
Kristof Van Avondt1, Jan-Kolja Strecker2, Claudia Tulotta1
1Institute of Experimental Pathology (ExPat), Centre of Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.
Immunological Reviews
|October 31, 2022
Summary
Aging dramatically increases life expectancy but also elevates risks for diseases like cancer. Neutrophils play a key role in aging-associated pathologies, offering potential therapeutic targets.
Area of Science:
- Immunology
- Gerontology
- Pathology
Background:
- Human life expectancy has significantly increased over millennia due to improved living conditions and healthcare.
- Aging is a major non-modifiable risk factor for various chronic diseases, including cardiovascular disease, neurodegenerative disorders, and cancer.
- Neutrophils, a type of white blood cell, have recently been implicated in the development of these age-related pathologies.
Purpose of the Study:
- To review the impact of aging on neutrophil production and function.
- To explore the role of neutrophils in driving age-associated diseases.
- To discuss potential therapeutic strategies targeting neutrophil-driven pathologies in aging.
Main Methods:
- Literature review of studies on aging, neutrophils, and age-related diseases.
- Analysis of the interplay between neutrophil function and the aging process.
- Synthesis of current knowledge on therapeutic interventions.
Main Results:
- Aging affects neutrophil production, leading to altered numbers and function.
- Neutrophils contribute to the pathogenesis of cardiovascular disease, neurodegeneration, and cancer in aging individuals.
- Dysfunctional neutrophils exacerbate age-related inflammation and tissue damage.
Conclusions:
- Neutrophil function and production are significantly altered by aging.
- Neutrophils are key drivers of multiple age-associated pathologies.
- Targeting neutrophil-mediated processes presents a promising therapeutic avenue for combating age-related diseases.
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