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Updated: Aug 23, 2025

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Published on: May 30, 2021
Structural region essential for amyloid fibril formation in cytochrome c elucidated by optical trapping
Shun Hirota1, Chun-Liang Chiu2, Chieh-Ju Chang2
1Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan. hirota@ms.naist.jp.
Abstract:
Amyloid fibril formation of cytochrome c is spatially and temporally controlled with a combined method of disulfide bond cross-linking of cysteine-introduced variants and optical trapping, identifying that the structural change in the region containing Ala83 is essential for the amyloid fibril formation.
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