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Lateral ventricle meningiomas in children: clinicopathological and neuroradiological features
Yufan Chen1, Shuaiwei Tian1, Jiajia Wang1
1Department of Pediatric Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
Insights
Lateral ventricle meningiomas (LVM) are rare in children. This study analyzed five pediatric cases, finding distinct imaging features and successful surgical outcomes with no recurrence, emphasizing the need for pathological confirmation.
Area of Science:
- Pediatric neurosurgery
- Neuroradiology
- Pediatric oncology
Background:
- Lateral ventricle meningiomas (LVM) are exceptionally rare in pediatric populations.
- Existing research predominantly focuses on adult LVM, leaving a knowledge gap in pediatric cases.
Purpose of the Study:
- To investigate the clinicopathological and imaging characteristics of lateral ventricle meningiomas in children.
- To contribute to the limited understanding of pediatric LVM.
Main Methods:
- Retrospective analysis of five pediatric patients with pathologically confirmed LVM.
- Collection of clinical, pathological, treatment, and imaging data (CT, MRI).
Main Results:
- Five pediatric LVM cases (4 male, 1 female; average age 7.6 years) were analyzed.
- Imaging revealed specific CT/MRI signals, including hyperintensity on DWI (80%) and homogeneous enhancement (80%). Hydrocephalus was present in 3 patients.
- All patients underwent gross total resection with no recurrence over an average follow-up of 47.4 months; all tumors were WHO grade I.
Conclusions:
- Pediatric LVM exhibit unique imaging features but remain challenging to diagnose clinically.
- Pathological analysis is crucial for definitive diagnosis of pediatric lateral ventricle meningiomas.
Purpose:
Lateral ventricle meningiomas (LVM) in children are very rare. The current research is mostly limited to adults, and there are very few related studies on children. The purpose of this study was to analyze the clinicopathological and imaging features of lateral ventricle meningiomas in children.
Methods:
A retrospective analysis of five children with pathologically confirmed lateral ventricle meningioma was performed, and we collected clinical data, including clinicopathological data, treatment prognosis data, and imaging features (including tumor location, signal intensity, enhancement degree, intratumoral cyst, calcification, peritumoral edema, and associated hydrocephalus).
Results:
Among the 5 patients with LVM, 4 were male and 1 was female with an average age of 7.6 years (range 2 to 12 years). All CT scans showed slight hyperintensity or isodensity, and only 1 patient had calcification. Two patients demonstrated cyst changes. Four patients had varying degrees of peritumoral edema. The average tumor volume was 164.1 cm3 (1.4-314.9 cm3). All 5 patients with LVM were iso- or hypointense on T1WI. The T2WI signals had no obvious features. Four patients had a high signal on DWI (80%). The contrast-enhanced signals were mostly homogeneously strong (80%). MRI showed hydrocephalus in 3 patients. All patients underwent gross total resection, and they were followed up regularly after the operation. The average follow-up time was 47.4 months. No recurrence was found in any of the children. All patients were pathologically confirmed to have meningiomas, and WHO grades were all grade I.
Conclusion:
Lateral ventricle meningiomas in children are very rare, and the imaging manifestations of the tumor have certain characteristics, but the clinical diagnosis is still difficult, and the diagnosis still requires pathological analysis.
