Transient chemotactic defect in a child with elevated IgE

Leukocyte function was studied in a child with elevated IgE and many infections. At age 7 months, chemotaxis was decreased, but improved first toward formylated peptides and finally toward complement. Polarization and nitroblue tetrazolium reduction also were transiently impaired. Functional and clinical improvements were concomitant although IgE remained elevated.