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Can the level of HbA1C predict diabetic retinopathy among type II diabetic patients?

Javad Setareh1, Ghazale Hoseinzade2, Batoul Khoundabi3,4

  • 1Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.

BMC Ophthalmology
|November 1, 2022
PubMed

Insights

A Hemoglobin A1C (HbA1C) level of 8.15% can predict diabetic retinopathy in Type 2 diabetes patients. This finding aids clinical decisions for managing diabetic complications in the Iranian population.

Area of Science:

  • Endocrinology
  • Ophthalmology
  • Clinical Medicine

Background:

  • The Hemoglobin A1C (HbA1C) test is crucial for evaluating diabetes management and predicting complications.
  • Diabetic Retinopathy (DR) is a significant complication of diabetes, necessitating effective predictive measures.

Purpose of the Study:

  • To assess the predictive value of HbA1C levels for Diabetic Retinopathy (DR) in Type 2 diabetes mellitus (T2DM) patients.
  • To determine an optimal HbA1C cutoff point for DR detection in the Iranian population.

Main Methods:

  • A cross-sectional study involving 168 T2DM patients.
  • Data collection via questionnaires and laboratory tests.
  • Statistical analysis including decision trees and ROC curves to identify optimal cutoff points.

Main Results:

  • The prevalence of DR was 29.8% among the study participants.
  • An optimal HbA1C cutoff point of 8.15% was identified for differentiating patients with and without DR.
  • Decision tree and ROC analysis confirmed this predictive threshold.

Conclusions:

  • An HbA1C level of 8.15% serves as an effective cutoff for predicting DR in Iranian T2DM patients.
  • This established cutoff can guide clinical judgment and management strategies for DR prevention.
  • The findings provide evidence-based support for utilizing HbA1C in DR screening protocols.
Abstract

Keywords:
DiabetesDiagnosisEpidemiologyHbA1CRetinopathy

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