Related Experiment Video
Updated: Aug 23, 2025
03:52
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
470
Osteosarcopenia and Long-COVID: a dangerous combination
Umberto Tarantino1,2, Virginia V Visconti1, Roberto Bonanni1
1Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Therapeutic Advances in Musculoskeletal Disease
|November 1, 2022
Summary
Severe COVID-19 and Long-COVID can cause lasting muscle and bone problems, potentially worsening aging effects on the musculoskeletal system. Further research is needed to understand these long-term impacts.
Area of Science:
- Biomedical Science
- Pathophysiology
- Musculoskeletal Health
Background:
- The COVID-19 pandemic caused by SARS-CoV-2 has led to over 580 million infections globally.
- Long-COVID, characterized by persistent symptoms post-infection, includes musculoskeletal issues like myalgias and bone fragility.
- SARS-CoV-2 infection may exacerbate age-related musculoskeletal decline, leading to osteosarcopenia.
Purpose of the Study:
- To review muscle and bone tissue alterations induced by SARS-CoV-2 infection and Long-COVID.
- To summarize current knowledge on the biological mechanisms underlying these musculoskeletal changes.
- To highlight the necessity of a multidisciplinary approach for managing COVID-19's long-term musculoskeletal consequences.
Main Methods:
- Literature review of studies on SARS-CoV-2, Long-COVID, and musculoskeletal health.
- Analysis of epidemiological data and pathophysiological mechanisms.
- Synthesis of current scientific knowledge on the topic.
Main Results:
- SARS-CoV-2 infection is associated with significant muscle and bone dysfunction.
- Long-COVID patients exhibit persistent musculoskeletal sequelae, including myalgias and joint dysfunction.
- The virus may accelerate age-related musculoskeletal deterioration, worsening osteosarcopenia.
Conclusions:
- COVID-19 and Long-COVID pose significant risks to musculoskeletal health.
- Understanding the underlying mechanisms is crucial for predicting and mitigating long-term consequences.
- A multidisciplinary approach is essential for addressing the complex musculoskeletal manifestations of COVID-19.
Related Concept Videos
01:20COPD: Pathogenesis and Clinical Features
447
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
447
01:22Chronic Obstructive Pulmonary Disease
1.4K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.4K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.9K
01:29Pulmonary Tuberculosis I
297
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
297
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.9K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.9K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.3K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.3K