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Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and

Congshan Jiang1, Kaichong Jiang1, Xiaowei Li2

  • 1National Regional Children's Medical Center (Northwest), Key Laboratory of Precision Medicine to Pediatric Diseases of Shaanxi Province, Xi'an Key Laboratory of Children's Health and Diseases, Shaanxi Institute for Pediatric Diseases, Xi'an Children's Hospital, Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an, 710003, China.

Journal of Pharmaceutical Analysis
|November 1, 2022
PubMed

Insights

This study evaluates diagnostic methods for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and reviews immunoprotection status against COVID-19 variants. Understanding population immunity guides vaccine strategies and booster recommendations.

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • The rapid mutation of SARS-CoV-2 poses challenges for COVID-19 diagnosis and control.
  • Accurate population-scale diagnosis is crucial for managing the pandemic.
  • Understanding immunoprotection is key to addressing future SARS-CoV-2 variants.

Purpose of the Study:

  • To analyze diagnostic techniques for COVID-19 at a population scale.
  • To review methods for evaluating immunoprotection against SARS-CoV-2 variants.
  • To discuss the current knowledge of population immunoprotection status.

Main Methods:

  • Analysis of reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
  • Evaluation of antigen-detection rapid diagnostic tests (Ag-RDTs).
  • Assessment of high-throughput sequencing (HTS) for etiological diagnosis.

Main Results:

  • Various diagnostic techniques were assessed for population-scale COVID-19 diagnosis.
  • Methods for evaluating endogenous and vaccine-induced antibody status were reviewed.
  • Current understanding of immunoprotection against COVID-19 complications was discussed.

Conclusions:

  • Knowledge of population immunoprotection status is vital for guiding vaccine development and policy.
  • This understanding can inform the design of biopharmaceutical antibody products.
  • Findings support evidence-based guidelines for vaccine boosters and national regulations.
Keywords:
COVID-19ComplicationsEtiological diagnosisImmunoprotectionSARS-CoV-2 variantsVaccine

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