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Statins Have an Anti-Inflammation in CKD Patients: A Meta-Analysis of Randomized Trials

Jianting Wang1, Ziwei Chen2, Yuliang Qiu1

  • 1The Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian province, China.

Biomed Research International
|November 1, 2022
PubMed

Insights

Statins therapy significantly reduces C-reactive protein (CRP) levels in patients with chronic kidney disease (CKD), indicating a notable anti-inflammatory effect. This finding suggests statins may help manage CKD complications and slow disease progression.

Area of Science:

  • Nephrology
  • Pharmacology
  • Inflammation Research

Background:

  • Persistent inflammation is a key comorbidity in chronic kidney disease (CKD), contributing to complications, mortality, and disease progression.
  • The anti-inflammatory effects of statins in CKD patients remain inconclusive from previous research.
  • This meta-analysis aims to definitively assess the anti-inflammatory impact of statin therapy in individuals with CKD.

Approach:

  • A comprehensive literature search was performed across major databases (Medline, Embase, Cochrane, clinical trials) to identify relevant randomized controlled trials.
  • Included studies focused on evaluating the anti-inflammatory effects of statins in CKD patients.
  • Robustness of the primary outcome was confirmed through subgroup, sensitivity, and trim-and-fill analyses.

Key Points:

  • The meta-analysis included 25 studies with 7921 participants.
  • Statin therapy was associated with a significant reduction in C-reactive protein (CRP) levels (-2.06 mg/L; 95% CI: -2.85 to -1.27, p < 0.01).
  • Subgroup, sensitivity, and trim-and-fill analyses confirmed the stability and reliability of the pooled CRP results.

Conclusions:

  • Statin supplementation demonstrates significant anti-inflammatory effects in patients with chronic kidney disease.
  • These anti-inflammatory actions of statins are clinically relevant for improving CKD complications, reducing mortality, and slowing disease progression.
  • Further research is recommended to investigate statins' effects on inflammation in CKD patients with normal lipid levels and their potential use specifically for inflammation inhibition.
Abstract

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