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Updated: Aug 23, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification

Long Chen1, Hanning Liu1, Cheng Sun1

  • 1Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, China and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

JACC. Basic to Translational Science
|November 1, 2022
PubMed

Keywords:
ADV, adenovirusALP, alkaline phosphataseASO, antisense oligonucleotideApoE−/−, apolipoprotein E-deficientBMP, bone morphogenic proteinsBMP2 pathwayCAVD, calcific aortic valve diseaseEZH2, enhancer of zeste 2FISH, fluorescence in situ hybridizationHCD, high-cholesterol dietND, normal dietPRC2, polycomb repressive complex 2RT-qPCR, reverse-transcriptase-quantitative polymerase chain reactionRUNX2, Runt-related transcription factor 2SNHG3, small nucleolar RNA host gene 3TGF, transforming growth factorcalcific aortic valve diseasehVICs, human aortic valve interstitial cellslncRNA, long noncoding RNAlong noncoding RNAosteoblast differentiationtherapeutic target

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