MOG-IgG positive optic neuritis after SARS-CoV-2 infection

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Marta Gilardi1, Antonio Cortese2, Elisabetta Ferraro2

  • 1Neuro-Ophthalmology Unit, Presidio Ospedaliero Oftalmico, Rome, Italy.

European Journal of Ophthalmology
|November 1, 2022
PubMed
Abstract

Insights

Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) infection may trigger myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) associated optic neuritis. This case report highlights a potential link between SARS-CoV-2 and the development of MOG-IgG positive optic neuritis.

Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Neurologic complications are increasingly recognized following severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) infection.
  • Atypical cases of optic neuritis (ON), a condition affecting the optic nerve, have been linked to SARS-CoV-2.
  • Some of these optic neuritis cases test positive for myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG).

Observation:

  • This study presents a single case report of optic neuritis.
  • The patient developed optic neuritis with positive MOG-IgG.
  • The onset of optic neuritis occurred 15 days after the initial presentation of SARS-CoV-2 infection.

Findings:

  • The case demonstrates a temporal association between SARS-CoV-2 infection and the development of MOG-IgG positive optic neuritis.
  • The findings suggest that SARS-CoV-2 infection may act as a trigger for the autoimmune response against MOG.

Implications:

  • This case suggests a potential causal link between SARS-CoV-2 infection and the production of autoantibodies against MOG.
  • Understanding this association could inform clinical management and diagnostic approaches for post-infectious neurologic complications.
  • Further research is warranted to elucidate the precise mechanisms by which SARS-CoV-2 may trigger MOG-IgG production and subsequent optic neuritis.
Keywords:
immunology < IMMUNOLOGYinfections disease/aids < NEURO OPHTHALMOLOGYneuro imaging < NEURO OPHTHALMOLOGYoptic neuritis < NEURO OPHTHALMOLOGYoptic neuropathy < NEURO OPHTHALMOLOGY

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