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Updated: Aug 23, 2025

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
MOG-IgG positive optic neuritis after SARS-CoV-2 infection
Marta Gilardi1, Antonio Cortese2, Elisabetta Ferraro2
1Neuro-Ophthalmology Unit, Presidio Ospedaliero Oftalmico, Rome, Italy.
Background:
Many neurologic complications have been described after severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) including atypical cases of optic neuritis (ON), positive to myelin oligodendrocyte glycoprotein (MOG) IgG.
Objective:
To report a case of MOG-IgG-associated ON and discuss why SARS-CoV-2 infection could be a potential trigger.
Methods:
Retrospective single case report.
Results:
We report a case of ON with positive MOG-IgG developed 15 days after presentation of SARS-CoV-2 infection.
Conclusion:
This report suggests that SARS-CoV-2 infection may have triggered autoantibodies production against MOG leading to ON.
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