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Reflex decrease of histamine-induced bronchoconstriction after laryngeal stimulation in humans.

M C Michoud, R Amyot, A Jeanneret-Grosjean

    The American Review of Respiratory Disease
    |September 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

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    Mechanical irritation of the larynx reflexly activates the nonadrenergic, noncholinergic, inhibitory nervous system in humans. This nervous system activation partially reverses histamine-induced bronchoconstriction.

    Area of Science:

    • Respiratory Physiology
    • Neuroscience
    • Pulmonology

    Background:

    • The nonadrenergic, noncholinergic, inhibitory nervous system's role in human airway regulation is not fully understood.
    • Investigating reflex activation pathways is crucial for understanding respiratory control.

    Purpose of the Study:

    • To determine if laryngeal stimulation can reflexly activate the nonadrenergic, noncholinergic, inhibitory nervous system in humans.
    • To investigate the role of this system in modulating airway resistance, particularly in response to bronchoconstriction.

    Main Methods:

    • Laryngeal stimulation was performed using a cytology brush inserted via bronchoscope.
    • Subjects received beta-adrenergic and cholinergic blockers; bronchoconstriction was induced by histamine.
    • Airway resistance (RL) was measured before and after stimulation.

    Related Experiment Videos

  • Superior laryngeal nerve block and local anesthesia were used in some subjects.

    • Main Results:

    • Mechanical laryngeal irritation caused a significant, short-lasting decrease in RL.
    • This effect was observed even with beta-adrenergic and cholinergic blockade.
    • The decrease in RL was abolished by superior laryngeal nerve block and vocal cord anesthesia.
    • The observed changes reflected lower airway resistance, independent of cough.

    Conclusions:

    • Mechanical laryngeal stimulation reflexly activates a nonadrenergic, noncholinergic pathway in humans.
    • This pathway partially reverses histamine-induced bronchoconstriction.
    • The nonadrenergic, noncholinergic, inhibitory nervous system modulates airway resistance through laryngeal reflexes.