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Periprosthetic joint infection: what next?

Vishal Rajput1,2, R M D Meek3, Fares S Haddad1,4,5,6

  • 1University College London Hospital, London, UK.

The Bone & Joint Journal
|November 1, 2022
PubMed

Insights

Periprosthetic joint infection (PJI) is a complex complication requiring ongoing research. Advances in definition and patient-centered care are noted, but challenges in identifying causative organisms and resolving issues persist for the orthopaedic community.

Area of Science:

  • Orthopaedic Surgery
  • Infectious Diseases
  • Biomaterials Science

Background:

  • Periprosthetic joint infection (PJI) presents significant challenges in prosthetic joint management.
  • Despite increased focus over the past decade, many questions regarding PJI remain unanswered.

Purpose of the Study:

  • To provide an updated perspective on the current state of periprosthetic joint infection (PJI) research.
  • To outline future research directions and ongoing challenges in managing PJI.

Main Methods:

  • Review and synthesis of current knowledge and ongoing research in PJI.
  • Discussion of evolving surgical strategies and patient-centered care approaches.

Main Results:

  • A workable definition for PJI is now available for consensus.
  • Surgical strategies are evolving, with a growing emphasis on patient-centered care.

Conclusions:

  • Continued focus on identifying causative organisms in PJI is essential.
  • Despite progress, PJI remains a major challenge for orthopaedics, necessitating further research and resolution of numerous problems.
Keywords:
National Joint RegistryPeriprosthetic joint infectionPeriprosthetic joint infection (PJI)Synovial fluidantibioticsarthroplastiesbiofilmsbiomarkersinfectionsmonoclonal antibodiesorganism(s)

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