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Inflammation in coronary artery disease-clinical implications of novel HDL-cholesterol-related inflammatory

Xuantong Guo1, Lihong Ma

  • 1National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Coronary Artery Disease
|November 1, 2022
PubMed

Insights

Novel inflammatory markers, including the monocyte to HDL-cholesterol ratio, can improve coronary artery disease (CAD) risk assessment. This review explores HDL-cholesterol

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biochemistry

Background:

  • Coronary artery disease (CAD) remains a leading global cause of mortality, primarily driven by inflammation and atherosclerotic plaque development.
  • Immune cell activation and recruitment, triggered by lipids and endothelial damage, are central to plaque formation.
  • High-density lipoprotein cholesterol (HDL-C) exhibits anti-inflammatory properties, modulating immune cell function in atherosclerosis.

Approach:

  • This review synthesizes current research on inflammatory processes in atherosclerosis.
  • It examines the role of HDL-cholesterol in modulating immune responses within atherosclerotic lesions.
  • The focus is on novel HDL-cholesterol-related inflammatory parameters for risk stratification.

Key Points:

  • Inflammatory cells and mediators are crucial for identifying CAD inflammatory risk.
  • Novel parameters, such as the monocyte to HDL-cholesterol ratio, offer improved prognostic value.
  • Understanding these inflammatory markers aids in personalized CAD management.

Conclusions:

  • Novel inflammatory parameters linked to HDL-cholesterol hold significant clinical implications for CAD prognosis.
  • Accurate identification of patients with high inflammatory risk can guide targeted therapeutic strategies.
  • This approach enhances the management of atherosclerosis and CAD.

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