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Living Leukocyte-Based Drug Delivery Systems
Yaxin Chen1, Duotian Qin2, Jianhua Zou3,4
1Institute of Biopharmaceutical and Health Engineering, Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Advanced Materials (Deerfield Beach, Fla.)
|November 1, 2022
Summary
Living leukocyte-based drug delivery systems show promise for treating cancer and inflammation. These systems leverage immune cells like macrophages, neutrophils, and lymphocytes for targeted therapy, offering improved efficacy and reduced side effects.
Area of Science:
- Biomedical Engineering
- Immunology
- Drug Delivery Systems
Background:
- Leukocytes are crucial for immune responses, tissue repair, and homeostasis.
- Leukocytes accumulate at sites of cancer and inflammation, contributing to disease progression.
- Existing treatments for cancer and inflammation face challenges in specificity and side effects.
Purpose of the Study:
- To review recent advances in living leukocyte-based drug delivery systems.
- To explore the potential of macrophages, neutrophils, and lymphocytes as therapeutic agents.
- To discuss the application of these systems in treating cancer and inflammation-related diseases.
Main Methods:
- Review of current literature on leukocyte-based drug delivery systems.
- Analysis of the advantages, challenges, and limitations of using leukocytes for drug delivery.
- Discussion of future perspectives for precision and targeted therapies.
Main Results:
- Living leukocyte-based drug delivery systems demonstrate innate targeting capabilities.
- These systems offer potential for improved therapeutic efficacy and reduced adverse effects.
- Macrophages, neutrophils, and lymphocytes are identified as promising cell types for drug delivery.
Conclusions:
- Living leukocyte-based drug delivery systems represent a promising strategy for treating cancer and inflammation.
- Further development is needed to overcome current challenges and optimize clinical application.
- These cell-based systems may revolutionize the treatment of complex diseases.
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