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Published on: December 1, 2016
Dual-receptor-targeted nanomedicines: emerging trends and advances in lung cancer therapeutics
Vikas1, Hemendra Kumar Sahu1, Abhishesh Kumar Mehata1
1Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (BHU), Varanasi, Uttar Pradesh, 221005, India.
Abstract:
Cancer is the leading cause of mortality worldwide. Among all cancer types, lung cancer is recognized as the most lethal and highly metastatic. The application of targeted nanomedicine loaded with anticancer drugs is highly desirable for successful lung cancer treatment. However, due to the heterogenicity and complexity of lung cancer, the therapeutic effectiveness of a single receptor targeting nanomedicine is unfortunately limited. Therefore, the concept of dual-receptor-targeted nanomedicine is an emerging trend for the advancement in lung cancer therapeutics. In this review, the authors discuss various single- and dual-receptor-targeted nanomedicines that have been developed for lung cancer treatment. Furthermore, the authors also discussed all the types of receptors that can be utilized in combination for the development of dual-receptor-targeted nanomedicines.
Insights
Dual-receptor-targeted nanomedicine offers improved lung cancer treatment by overcoming the limitations of single-receptor approaches. This strategy enhances therapeutic effectiveness against this lethal and metastatic disease.
Area of Science:
- Oncology
- Nanomedicine
- Drug Delivery
Background:
- Lung cancer is a leading global cause of mortality and is highly metastatic.
- Targeted nanomedicine offers a promising approach for lung cancer treatment.
- The heterogeneity of lung cancer limits the effectiveness of single-receptor targeted nanomedicines.
Purpose of the Study:
- To review single- and dual-receptor-targeted nanomedicines for lung cancer treatment.
- To discuss receptor combinations for dual-targeting strategies.
Main Methods:
- Literature review of targeted nanomedicine research in lung cancer.
- Analysis of receptor expression patterns in lung cancer.
- Evaluation of nanomedicine strategies for dual-receptor targeting.
Main Results:
- Single-receptor nanomedicines show limited efficacy due to lung cancer complexity.
- Dual-receptor-targeted nanomedicines represent an emerging and promising therapeutic trend.
- Various receptor combinations are being explored for enhanced lung cancer therapy.
Conclusions:
- Dual-receptor targeting enhances the therapeutic potential of nanomedicines for lung cancer.
- Strategic selection of receptor combinations is crucial for effective dual-targeted nanomedicine development.
- This approach holds significant promise for advancing lung cancer treatment outcomes.
