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Related Experiment Video

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Bioreactor Assembly for Continuous Culture of Complex Fecal Communities
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A low-cost, open-source evolutionary bioreactor and its educational use.

Vishhvaan Gopalakrishnan1, Dena Crozier1,2, Kyle J Card3

  • 1Lerner College of Medicine, Cleveland Clinic, Cleveland, United States.

Elife
|November 1, 2022
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Summary
This summary is machine-generated.

A low-cost morbidostat, the EVolutionary biorEactor (EVE), was developed for educational settings. This system enables students to study bacterial growth and the evolution of antibiotic resistance using readily available materials.

Keywords:
E. colieducationengineeringevolutionevolutionary biologygeneticsinfectious diseasemicrobiologyscience forumsoftware

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Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Biotechnology Education

Background:

  • Morbidostats are valuable tools for studying antibiotic resistance evolution.
  • High costs of traditional morbidostats limit their use in educational environments.
  • There is a need for accessible platforms for hands-on learning in microbial evolution.

Purpose of the Study:

  • To develop and validate a low-cost morbidostat, the EVolutionary biorEactor (EVE).
  • To enable students to investigate bacterial growth and antibiotic resistance evolution.
  • To provide an accessible experimental platform for educational settings.

Main Methods:

  • Construction of the EVolutionary biorEactor (EVE) using accessible components.
  • Validation of EVE in a classroom setting with minimal student engineering and programming.
  • Evolving replicate *Escherichia coli* populations under chloramphenicol selective pressure.

Main Results:

  • Successful construction and validation of the low-cost EVE system.
  • Demonstrated ability of EVE to facilitate the study of bacterial evolution.
  • Students gained practical experience in microbiology and antibiotic resistance research.

Conclusions:

  • The EVolutionary biorEactor (EVE) is a cost-effective and feasible tool for microbiology education.
  • EVE empowers students to explore fundamental concepts in bacterial evolution and antibiotic resistance.
  • This low-cost approach democratizes access to advanced biological research techniques in academic settings.