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Determination of Metoclopramide Hydrochloride in Pharmaceutical Formulations using N-Oxidation Caroate
Mykola Blazheyevskiy1, Deghinmotei Alfred-Ugbenbo2, Olena Oleksandrivna Mozgova1
1National University of Pharmacy, Department of Inorganic and Physical Chemistry, Kharkiv, Ukraine.
Objectives:
To develop two (titrimetric and spectrophotometric) simple, rapid, sensitive and cost-effective methods for the determination of metoclopramide (MCP) in pharmaceutical dosage forms.
Materials And Methods:
The titrimetric method (A) was based on the N-oxidation reaction involving the use of potassium hydrogen peroxymonosulfate and subsequent iodometric back titration of a known residual reagent. The spectrophotometric method (B) was based on derivatization of MCP with potassium hydrogen peroxymonosulfate in the presence of iodide to produce a chromogen (triiodide) with a wavelength of maximum absorption at 350 nm.
Results:
Method "A" was applicable over the concentration range of 0.25-3.5 mg to end volume 10 mL. In method "B", Beer's law was obeyed over the concentration range of 0.3-3.5 μg/mL with molar absorptivity of 24600 L/mol cm. The limits of quantification were calculated to be 0.25 mg/10 mL (A) and 0.2 μg/mL (B), respectively.
Conclusion:
The proposed methods were suitable for determination of MCP as a pure substance in tablets and injection.
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