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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Ensembl 2023.

Fergal J Martin1, M Ridwan Amode1, Alisha Aneja1

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Summary
This summary is machine-generated.

Ensembl provides comprehensive genomic resources, evolving to include diverse species and pangenome data. This enhances research with updated annotations, variant prediction, and protein structure insights.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Comparative Genomics

Background:

  • Ensembl has provided genomic resources for over 20 years.
  • The genomic landscape has shifted with increased reference genomes and pangenome initiatives.
  • There is a growing need for comprehensive genomic data across diverse species.

Purpose of the Study:

  • To report on Ensembl's updated genomic resources and services.
  • To support global biodiversity and pangenome efforts.
  • To accelerate downstream research through advanced genomic tools.

Main Methods:

  • Continued development of high-quality annotations for vertebrates and model organisms.
  • Integration of pangenome data, including human haplotype graphs.
  • Updates to the Ensembl Variant Effect Predictor (VEP).

Main Results:

  • Expansion of genomic resources to include a wider range of species.
  • Significant growth in annotation data, incorporating novel haplotype information.
  • Enhanced tools for variant effect prediction and interactive protein structure visualization via AlphaFold DB.

Conclusions:

  • Ensembl is adapting to the evolving genomic landscape by expanding its resources and tools.
  • The platform facilitates research by providing up-to-date, high-quality genomic data and services.
  • New website beta release aims to improve user experience and accessibility.