The Neuroscience Multi-Omic Archive: a BRAIN Initiative resource for single-cell transcriptomic and epigenomic data...

Area of Science:

• Neuroscience
• Genomics
• Bioinformatics

Background:

• Single-cell sequencing technologies are revolutionizing brain research.
• The NIH's BRAIN Initiative aims to map mammalian brain cell types at scale.
• Data accessibility and FAIRness are crucial for collaborative research.

Purpose of the Study:

• To describe the Neuroscience Multi-Omic Archive (NeMO Archive) as a central repository for BRAIN Initiative genomics data.
• To enhance data FAIRness (Findable, Accessible, Interoperable, Reusable) for the neuroscience community.
• To provide tools for accessing and analyzing large-scale brain cell data.

Main Methods:

• Curated and organized large-scale transcriptomic and epigenomic data from single brain cells.
• Established a primary repository (NeMO Archive) for BRAIN Initiative genomics data.
• Developed accessible data retrieval and analysis tools, including a web portal, cloud interface (Terra), and NeMO Analytics.

Main Results:

• The NeMO Archive contains genomics data from over 50 million brain cells.
• Data includes single-cell transcriptomic and epigenomic information from human, mouse, and non-human primate brains.
• Multiple tools are available for data access, processing, and analysis.

Conclusions:

• The NeMO Archive significantly advances data FAIRness for neuroscience research.
• It provides a comprehensive, accessible resource for studying brain cell types and states.
• The integrated tools facilitate large-scale data exploration and discovery.