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In vitro Investigation of the MexAB Efflux Pump From Pseudomonas aeruginosa
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Exploring functional interplay amongst Escherichia coli efflux pumps

James A Goetz1, Noah M Kuehfuss1, Alexander J Botschner1

  • 1College of Biological Sciences, Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Rd E, Guelph, Ontario, N1G 2W1, Canada.

Microbiology (Reading, England)
|November 1, 2022
PubMed
Summary

Combining different types of bacterial efflux pumps can significantly increase antimicrobial resistance. This study reveals that certain combinations of single-component and tripartite efflux systems lead to multiplicative increases in drug resistance, highlighting potential therapeutic targets.

Keywords:
antibiotic resistanceefflux pumpsfunctional interplayphysiological functions

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