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Updated: Aug 23, 2025

Measuring Cell-Edge Protrusion Dynamics during Spreading using Live-Cell Microscopy
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WNK kinases sense molecular crowding and rescue cell volume via phase separation

Cary R Boyd-Shiwarski1, Daniel J Shiwarski2, Shawn E Griffiths3

  • 1Department of Medicine, Renal-Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Pittsburgh Center for Kidney Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

Cell
|November 1, 2022
PubMed

Keywords:
K-Cl cotransportNa-K-2Cl cotransportSLC12 cotransporterWNK kinasebiomolecular condensatescell volume regulationhyperosmotic stressmacromolecular crowdingphase separation

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