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[Comparative antibiotic sensitivity of NAG vibrios]
Antibiotiki I Meditsinskaia Biotekhnologiia = Antibiotics and Medical Biotechnology
|April 1, 1987
Summary
Non-agglutinable (NAG) Vibrio strains show high resistance to penicillins and polymyxin M but are sensitive to gentamicin, levomycetin, and tetracyclines. These environmental and clinical isolates can acquire antibiotic resistance plasmids.
Area of Science:
- Microbiology
- Environmental Science
- Clinical Medicine
Background:
- Non-agglutinable (NAG) Vibrio are significant in both clinical and environmental settings.
- Understanding their antibiotic resistance profiles is crucial for public health.
- NAG Vibrio strains are isolated from diverse sources, including patients, carriers, water, and sewage.
Purpose of the Study:
- To investigate the antibiotic sensitivity patterns of 648 NAG Vibrio strains.
- To determine the susceptibility of NAG Vibrio to 14 different antibiotics.
- To assess the potential of NAG Vibrio to acquire antibiotic resistance via R plasmids.
Main Methods:
- Antibiotic sensitivity testing using serial dilutions in solid media.
- Isolation of NAG Vibrio strains from clinical and environmental sources.
- Evaluation of NAG Vibrio's capacity to receive exogenous R plasmids.
Main Results:
- NAG Vibrio strains exhibited high resistance to penicillins and polymyxin M.
- These strains were highly sensitive to gentamicin, levomycetin, and tetracyclines.
- NAG Vibrio demonstrated the ability to act as recipients for R plasmids from various incompatibility groups.
Conclusions:
- NAG Vibrio possess a distinct antibiotic resistance profile, with notable sensitivity to specific antibiotics.
- The capacity of NAG Vibrio to acquire R plasmids highlights a potential mechanism for the spread of antibiotic resistance.
- Findings are critical for guiding treatment strategies and monitoring antimicrobial resistance in Vibrio species.