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Antimicrobial and prebiotic activity of mannoproteins isolated from conventional and nonconventional yeast

Anna Bzducha Wróbel1, Pavol Farkaš2, Paulina Chraniuk3

  • 1Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences, Nowoursynowska 159C Street, 02-787, Warsaw, Poland. anna_bzducha_wrobel@sggw.edu.pl.

World Journal of Microbiology & Biotechnology
|November 2, 2022
PubMed

Insights

Yeast mannoproteins show antimicrobial and prebiotic potential, influencing bacterial growth differently based on type and dose. Saccharomyces cerevisiae mannoproteins inhibited E. coli and Salmonella, while others targeted Staphylococcus aureus.

Area of Science:

  • * Microbiology and Food Science
  • * Biotechnology and Biopreservation

Background:

  • * Yeast mannoproteins are recognized for potential paraprobiotic properties, including antimicrobial and prebiotic effects.
  • * Their application as food biopreservatives and in therapeutic contexts is emerging.
  • * Limited knowledge exists regarding the specific influence of different yeast mannoproteins on diverse microbial growth.

Purpose of the Study:

  • * To investigate the impact of mannoprotein preparations from Saccharomyces cerevisiae, Metschnikowia reukaufii, and Wickerhamomyces anomalus on the growth of selected bacterial strains.
  • * To determine the dose-dependent and strain-specific effects of these mannoproteins on bacterial proliferation.
  • * To identify potential applications of these mannoproteins as biopreservatives and in modulating gut microbiota.

Main Methods:

  • * Preparation and application of mannoproteins from S. cerevisiae ATCC 7090, M. reukaufii WLP 4650, and W. anomalus CCY 38-1-13.
  • * Cultivation of selected bacteria including Lactobacillus, Bifidobacterium, Staphylococcus, Enterococcus, Pseudomonas, Escherichia, Proteus, and Salmonella genera.
  • * Assessment of bacterial growth stimulation or inhibition in response to varying concentrations of mannoprotein preparations.

Main Results:

  • * Mannoprotein preparations differentially affected bacterial growth, with effects varying by yeast origin, bacterial strain, and concentration.
  • * Lactobacillus arabinosus ATCC 8014 and Bifidobacterium animalis subsp. lactis B12 growth were consistently stimulated by all tested preparations.
  • * S. cerevisiae mannoproteins significantly inhibited E. coli, P. aureoginosa, P. mirabilis, and S. Enteritidis; M. reukaufii and W. anomalus mannoproteins were most effective against S. aureus, E. coli, and P. aureoginosa.

Conclusions:

  • * Yeast mannoproteins exhibit selective antimicrobial and growth-promoting activities against specific bacteria.
  • * The findings support the potential of yeast mannoproteins as functional food ingredients and biopreservatives.
  • * Further research is needed to elucidate the structural basis and mechanisms underlying these observed microbial interactions.
Keywords:
Antimicrobial activityMannoproteinsMetschnikowia reukaufiiPrebioticSaccharomyces cerevisiaeWickerhamomyces anomalus

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